Categories: Organic Chemistry
Organic Reaction Mechanisms
M. Gomez Gallego, M. A. Sierra
Hardcover, 290 Pages
First Edition, 2004
Organic Reaction Mechanisms shows readers how to interpret the experimental data obtained from an organic reaction, and specifically how an organic reaction mechanism can be considered or rejected based on the analysis of the experimental evidence. Whilst examining a series of selected examples of mechanisms, the text focuses on real cases and discusses them in detail. The examples are arranged to elucidate key aspects of organic reaction mechanisms. The authors employ all the types of information that the authors of the original work considered useful and necessary, including spectroscopic data, kinetic and thermodynamic data, isotopic labelling and organic reactivity. The book makes an excellent primer for advanced undergraduates in chemistry who are preparing for exams and is also useful for graduate students and instructors.
Every organic chemist is familiar with the basic mechanisms: SN2, SN1, eliminations, aromatic substitutions... But there are reactions, where the product spectrum lets assume that the reactions take place by another, perhaps unexpected mechanism. Assumptions were set up and experiments with labeled compounds were done to find out about the kinetics of the reaction and the reaction mechanism.
These methods are described very detailed and alive in "Organic Reaction Mechanisms". Based on interesting examples from the current literature, findings, considerations and control experiments were explained and the most probable mechanism is then selected. The examples reach from the influence of lewis acids in the nucleophilic addition to carbonyles up to the esterification of a carbonic acid with dimethyl carbonate and DBU. Thus, they cover a large range of reactions and are arranged according to the rising degree of difficulty.
The ones who love organic chemistry, will devour the book like a crime film. Only very painstakingly work and logical conclusions lead to the correct mechanism. 40 cases became in "Organic Reaction Mechanisms" excitingly delineated. Because the solution is presented at the end of the current case, the reader is obliged to puzzle!