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Enantioselective Organocatalyzed Reactions

Rainer Mahrwald

Hardcover, 322 Pages
1st Edition, 2011
ISBN: 978-90-481-3864-7

Rainer Mahrwald

Hardcover, 386 Pages
1st Edition, 2011
ISBN: 978-90-481-3866-1


Organocatalysis has emerged as one of the hot topics in organic chemistry in recent years, as confirmed by the rapid-growing interest that researchers have shown in this field.
Enantioselective Organocatalyzed Reaction Volume I and II provides a critical review of the state-of-the-art developments in Organocatalysis, with a special focus on the asymmetric transformation that it enables. These volumes, written by leading experts in the field, discuss a broad range of synthetic transformations and offer an up-to-date coverage of organocatalyzed reactions such as: Conjugate addition; Aldol addition; Oxidation; Reduction; Cycloaddition; Mannich reaction; Asymmetric funtionalization; Enantioselective protonation; General aspects of asymmetric cyclization; Asymmetric desymmetrization processes.

By presenting a complete panorama of the use of organocatalysts in organic reaction, Enantioselective Organocatalyzed Reaction will help the global audience of scientists engaged in this area of research to develop new catalysts as well as new fields of applications in organic synthesis.

Editorial Review

Organocatalysis is a fascinating area of research that has resulted in a multitude of publications to date, from which it is clear that new catalysts and knowledge of the mechanisms lead to ongoing improvements in synthetic reactions. So it is with the recent efforts in SOMO activation by David MacMillan, which have opened up a mechanistically interesting field of research for the further development of catalysts. A current overview of the important reaction types that covers a variety of catalysts, and takes a close look at some of the specific mechanistic factors, is thus required reading for all researchers who are interested in organocatalysis. Likewise, whether from an interest in the development of new, green chemical processes, the use of organocatalysts for novel reactions, or the optimization of existing organocatalytic synthetic reactions, readers will find helpful suggestions in these books, "Enantioselective Organocatalyzed Reactions".

Under Rainer Mahrwald’s guidance, the authors have gathered together hundreds of reactions, documented a wide variety of catalysts, and provided clear descriptions and schemes to illustrate the underlying mechanisms. Some of the authors have expended great effort to offer a detailed examination of the mechanisms, while others present an extensive list of examples. To the extent that the books vary between these two extremes, there is some inhomogeneity, but all of the chapters are crafted to inspire many new ideas and suggestions for the reader’s own work.

The single criticism is that the volumes must be purchased individually. It is quite conceivable, though, that one buyer might only be interested in "Asymmetric C-C Bond Formation Processes" (Volume 1), while another might wish to acquire "Enantioselective Oxidation, Reduction, Functionalization and Desymmetrization" (Volume 2). The volumes are logically distinct from one another in terms of subject matter, and in any case, the purchase of both books is well worthwhile for large research groups and libraries..


Organocatalytic Cyclisations (Alexander J. Andre Cobb, University of Reading, UK).- Organocatalyzed Conjugate Additions (Diego Alonso,University of Alicante, Spain).- Organocatalyzed Cycloadditions (Bor-cherng Hong, National Chung Cheng University, Taiwan).- Organocatalyzed Aldoladditions (Carmen Nájera, University of Alicante, Spain).- Organocatalyzed Domino-Reactions (Bernhard Westermann, Leibniz-Institut für Pflanzenbiochemie, Halle (Saale) Germany).- Organocatalyzed Mannich-Reactions (Floris PJT Rutjes, Radboud University Nijmegen, Nijmegen, Netherlands).