Organic Chemistry Portal
Chemicals >> Oxidizing Agents

1-Hydroxycyclohexyl phenyl ketone (1-HCPK)

The commercially available 1-hydroxycyclohexyl phenyl ketone is an excellent acceptor in hydrogen transfer oxidations. For example, the reagent can be used for convenient oxidations of primary alcohols and aldehydes to the corresponding carboxylic acids in the presence of NaOH.


Recent Literature


A metal-free, chemoselective oxidation of primary alcohols and aldehydes with cheap 1-hydroxycyclohexyl phenyl ketone as oxidant to the corresponding carboxylic acids features an easy to handle procedure, high isolated yields, and good to excellent functional group tolerance even in the presence of vulnerable secondary alcohols and tert-butanesulfinamides.
W.-Y. Tan, Y. Lu, J.-F. Zhao, W. Chen, H. Zhang, Org. Lett., 2021, 23, 6648-6653.


A metal-free, chemoselective oxidation of primary alcohols and aldehydes with cheap 1-hydroxycyclohexyl phenyl ketone as oxidant to the corresponding carboxylic acids features an easy to handle procedure, high isolated yields, and good to excellent functional group tolerance even in the presence of vulnerable secondary alcohols and tert-butanesulfinamides.
W.-Y. Tan, Y. Lu, J.-F. Zhao, W. Chen, H. Zhang, Org. Lett., 2021, 23, 6648-6653.