1-Hydroxycyclohexyl phenyl ketone (1-HCPK)
The commercially available 1-hydroxycyclohexyl phenyl ketone is an excellent acceptor in hydrogen transfer oxidations. For example, the reagent can be used for convenient oxidations of primary alcohols and aldehydes to the corresponding carboxylic acids in the presence of NaOH.
Recent Literature
A metal-free, chemoselective oxidation of primary alcohols and aldehydes with
cheap 1-hydroxycyclohexyl phenyl ketone as oxidant to the corresponding
carboxylic acids features an easy to handle procedure, high isolated yields, and
good to excellent functional group tolerance even in the presence of vulnerable
secondary alcohols and tert-butanesulfinamides.
W.-Y. Tan, Y. Lu, J.-F. Zhao, W. Chen, H. Zhang, Org. Lett., 2021, 23,
6648-6653.
A metal-free, chemoselective oxidation of primary alcohols and aldehydes with
cheap 1-hydroxycyclohexyl phenyl ketone as oxidant to the corresponding
carboxylic acids features an easy to handle procedure, high isolated yields, and
good to excellent functional group tolerance even in the presence of vulnerable
secondary alcohols and tert-butanesulfinamides.
W.-Y. Tan, Y. Lu, J.-F. Zhao, W. Chen, H. Zhang, Org. Lett., 2021, 23,
6648-6653.