2,5-di-tert-butyl-1,4-benzoquinone, 2,5-DTBQ
see also: benzoquinone
Recent Literature
A palladium-catalyzed oxidative N-α,β-dehydrogenation of amides
provides a range of enamides with high yields and excellent tolerance toward
different functional groups. The reaction involves allylic C(sp3)-H
activation followed by β-H elimination.
Y. Jin, M. Li, Y. Chen, J. Li, W. Wu, H. Jiang, Org. Lett., 2024,
26, 4218-4223.
A Pd-catalyzed α,β-desaturation of N-protected lactams provides
conjugated unsaturated counterparts under mildly acidic conditions at room
temperature. The reaction tolerates a wide range of functional groups and shows
reactivity complementary to that of prior desaturation methods. Lactams with
various ring sizes and substituents at different positions all reacted smoothly.
M. Chen. G. Dong, J. Am. Chem. Soc., 2017,
139, 7757-7760.
