A transition metal-free one-pot reaction of secondary alcohols and 2-aminoalcohols provides various substituted NH-pyrroles via an Oppenauer oxidation in the presence of benzophenone as an inexpensive reagent. The oxidation of the secondary alcohols under mild condition to ketones is followed by an in situ condensation with aminoalcohol, and oxidative cyclization to the target pyrrole ring.
J.-A. Shin, J. Kim, H. Lee, S. Ha, H.-Y. Lee, J. Org. Chem., 2019, 84, 4558-4565.