Hydrogen peroxide urea adduct, UHP
Urea-hydrogen peroxide is a non-toxic, odorless crystalline solid. This adduct, which contains 35% of H2O2, sets the hydrogen peroxide free during its application.
Recent Literature
Urea-hydrogen peroxide in the presence of a catalytic amount of magnesium
bromide efficiently oxidizes primary and secondary
benzylic alcohols into the corresponding aromatic aldehydes and ketones.
H. J. Park, J. C. Lee, Synlett, 2009,
79-80.
Methyltrioxorhenium (MTO) catalyzes an oxidation of methyl trimethylsilyl ketene
acetals with urea hydrogen peroxide to afford α-hydroxy and α-siloxy esters. On
treatment with potassium fluoride, the α-hydroxy esters are obtained in high
yields.
S. Stanković, J. H. Espenson, J. Org. Chem., 2000,
65, 5528-5530.
Eco-friendly laboratory procedures allow the oxidative iodination
of various activated and deactivated arenes with molecular iodine, in the
presence of UHP (percarbamide), a stable, strongly H-bonded, solid urea-hydrogen
peroxide adduct as the oxidant.
P. Lulinski, A. Kryska, M. Sosnowski, L. Skulski, Synthesis, 2004,
441-445.
Urea-hydrogen peroxide adduct (UHP) is stable, inexpensive and an easily handled
reagent. UHP is used in an efficient solid state oxidation of different
organic molecules: hydroxylated aldehydes and ketones (to hydroxylated phenols),
sulfides (to sulfoxides and sulfones), nitriles (to amides) and nitrogen
heterocycles (to N-oxides).
R. S. Varma, K. P. Naicker, Org. Lett.,
1999,
1, 189-191.
A combination of 1,1,1,3,3,3-hexafluoroispropanol (HFIP) and H2O2
enables a straightforward synthesis of N,N-disubstituted formamides from
imines in
very good yields via an oxidation-rearrangement sequence under smooth reaction
conditions.
N. Llopis, P. Gisbert, A. Baeza, J. Org. Chem., 2020, 85,
11072-11079.
Urea-hydrogen peroxide adduct (UHP) is stable, inexpensive and an easily handled
reagent. UHP is used in an efficient solid state oxidation of different
organic molecules: hydroxylated aldehydes and ketones (to hydroxylated phenols),
sulfides (to sulfoxides and sulfones), nitriles (to amides) and nitrogen
heterocycles (to N-oxides).
R. S. Varma, K. P. Naicker, Org. Lett.,
1999,
1, 189-191.
Urea-hydrogen peroxide adduct (UHP) is stable, inexpensive and an easily handled
reagent. UHP is used in an efficient solid state oxidation of different
organic molecules: hydroxylated aldehydes and ketones (to hydroxylated phenols),
sulfides (to sulfoxides and sulfones), nitriles (to amides) and nitrogen
heterocycles (to N-oxides).
R. S. Varma, K. P. Naicker, Org. Lett.,
1999,
1, 189-191.
The use of urea-hydrogen peroxide and phthalic anhydride in ethyl acetate
enables a metal-free, environmentally benign oxidation of substituted sulfides
to their corresponding sulfones without observation of the possible
sulfoxide oxidation product.
M. Lutz, M. Wenzler, I. Likthotvorik, Synthesis, 2018, 50,
2231-2234.
The use of urea-hydrogen peroxide as terminal oxidant in the presence of
diphenyl diselenide as catalyst enables a highly selective catalytic oxidation
of sulfides into the corresponding sulfoxides.
P. C. B. Page, B. R. Buckley, C. Elliott, Y. Chan, N. Dreyfus, F. Marken,
Synlett, 2016, 27, 80-82.
Urea-hydrogen peroxide adduct (UHP) is stable, inexpensive and an easily handled
reagent. UHP is used in an efficient solid state oxidation of different
organic molecules: hydroxylated aldehydes and ketones (to hydroxylated phenols),
sulfides (to sulfoxides and sulfones), nitriles (to amides) and nitrogen
heterocycles (to N-oxides).
R. S. Varma, K. P. Naicker, Org. Lett., 1999, 1, 189-191
A general, high yielding, and user and environmentally friendly catalytic
oxidation procedure for the chemoselective oxidation of imines to nitrones is
reported.
G. Soldaini, F. Cardona, A. Goti, Org. Lett., 2007,
9, 473-476.
A modified procedure for the direct synthesis of hypervalent [bis(trifluoroacetoxy)iodo]arenes
avoids the use of hazardous reagents with the workup being only an aqueous
extraction.
T. Keri Page, T. Wirth,
Synthesis, 2006, 3080-3084.
