Phthaloyl peroxide, PPO
Recent Literature
A flow protocol for the generation of phthaloyl peroxide in high purity (>95%)
can be used to bypass the need to isolate and recrystallize phthaloyl peroxide,
improving upon earlier batch procedures. The flow protocol for the formation of
phthaloyl peroxide can be combined with arene hydroxylation reactions.
A. M. Eliasen, R. P. Thedford, K. R. Claussen, C. Yuan, D. Siegel, Org. Lett., 2014,
16, 3628-3631.
A metal-free ring opening/halogenation of cycloalkanols, which combines both PPO/TBAX
oxidant system and blue LEDs irradiation, provides diverse γ, δ, and even more
remotely halogenated ketones in good yields under mild conditions.
R. Zhao, Y. Yao, D. Zhu, D. Chang, Y. Liu, L. Shi, Org. Lett.,
2018, 20, 1228-1231.
The combination of phthaloyl peroxide with commercially available halide salts
provides an unique halogenating system for Hofmann-Löffler-Freytag-type
reactions to produce N-chloroamides, δ-brominated products, and even
biologically relevant pyrrolidines under mild conditions in good yields.
D. Chang, R. Zhao, C. Wei, Y. Yao, Y. Liu, L. Shi, J. Org. Chem., 2018, 83,
3305-3315.
The combination of phthaloyl peroxide with commercially available halide salts
provides an unique halogenating system for Hofmann-Löffler-Freytag-type
reactions to produce N-chloroamides, δ-brominated products, and even
biologically relevant pyrrolidines under mild conditions in good yields.
D. Chang, R. Zhao, C. Wei, Y. Yao, Y. Liu, L. Shi, J. Org. Chem., 2018, 83,
3305-3315.
