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Chemicals >> Oxidizing Agents

Sodium peroxydisulfate

See also: ammonium peroxydisulfate, choline peroxydisulfate, potassium peroxydisulfate, tetrabutylammonium peroxydisulfate

Recent Literature


A silver-catalyzed double-decarboxylative protocol enables an efficient and pratical construction of chalcone derivatives via cascade coupling of substituted α-keto acids with cinnamic acids under mild and environmentally benign aqueous conditions.
N. Zhang, D. Yang, W. Wei, L. Yuan, F. Nie, L. Tian, H. Wang, J. Org. Chem., 2015, 80, 3258-3263.


An efficient Na2S2O8-promoted radical coupling of tertiary cycloalkanols with alkynyl hypervalent iodide reagents provides β-, γ- and δ-alkynylated ketones via C-C bond cleavage. This tandem ring-opening/alkynylation procedure offers mild conditions and wide substrate scope.
S. Wang, L.-N. Guo, H. Wang, X.-H. Duan, Org. Lett., 2015, 17, 4798-4801.


In a copper-free Sandmeyer-type fluorosulfonylation reaction with Na2S2O5 as the sulfur dioxide source and Selectfluor as fluorine source, aryldiazonium salts are transformed into sulfonyl fluorides. In situ diazotization enables the use of aromatic amines as substrates. The method offers broad functional group tolerance, gram-scale synthesis and late-stage fluorosulfonylation.
T. Zhong, M.-K. Pang, Z.-D. Chen, B. Zhang, J. Weng, G. Lu, Org. Lett., 2020, 22, 2941-2945.


A Pd-catalyzed C-H bond activation/C-C bond formation/cyclization cascade process enables the synthesis of quinolinone derivatives from simple anilines as the substrates. This method provides access to quinolinone-containing alkaloids and drug molecules.
J. Wu, S. Xiang, J. Zeng, M. Leow, X.-W. Liu, Org. Lett., 2015, 17, 222-225.


A transition-metal-free alkylation and acylation of C(sp2)-H bonds in biologically relevant 2-benzoxazinones with 1,4-dihydropyridines offers excellent functional group compatibility and a broad substrate scope.
Y. Byun, J. Moon, W. An, N. K. Mishra, H. S. Kim, P. Ghosh, I. S. Kim, J. Org. Chem., 2021, 86, 12247-12256.


The use of vinyl ethers as robust, inexpensive acetyl sources enables a mild, operationally simple Minisci C-H acetylation of N-heteroarenes. The reaction does not require a catalyst or high temperature and is therefore significantly more sustainable than previously reported methods in terms of cost, reagent toxicity, and waste generation.
J. Dong, J. Liu, H. Song, Y. Liu, Q. Wang, Org. Lett., 2021, 23, 4374-4378.


The use of vinyl ethers as robust, inexpensive acetyl sources enables a mild, operationally simple Minisci C-H acetylation of N-heteroarenes. The reaction does not require a catalyst or high temperature and is therefore significantly more sustainable than previously reported methods in terms of cost, reagent toxicity, and waste generation.
J. Dong, J. Liu, H. Song, Y. Liu, Q. Wang, Org. Lett., 2021, 23, 4374-4378.


An iron-catalyzed oxidative cyclization of 1-acyl-3-(phenyl)thioureas in the presence of sodium persulfate gave various N-benzothiazol-2-yl-amides selectively in good yields through C(sp2)-H functionalization and C-S bond formation.
J. Wang, Y. Zong, X. Zhang, Y. Gao, Z. Li, G. Yuo, Z. Quan, X. Wang, Synlett, 2014, 25, 2143-2148.