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Chemicals >> Reducing Agents

Carbon disulfide, Methanedithione, CS2

Recent Literature


The combination of CS2, t-BuOK and DMSO as solvent mediates a reduction of unsaturated ketone derivatives to provide saturated ketones. The in situ generation of xanthate salts through the reaction of carbon disulfide and potassium tert-butoxide is essential. Deuterium-labeling experiments demonstrated that DMSO can act as a hydrogen donor.
S. Rajai-Daryasarei, M. S. Hosseini, S. Balalaie, J. Org. Chem., 2023, 88, 10828-10835.


Phenyliodine(III) diacetate (PIDA) initiates a disproportionate coupling of readily available and inexpensive sulfonyl hydrazides to provide thiosulfonates in very good yields. This transition-metal-free synthesis involves cleavage of the S-N bond and formation of a new S-S bond. The thiosulfonates were further reduced with CS2/KOH to obtain symmetrical disulfides.
A. Yadav, R. Kumar, V. Prasad, Synthesis, 2024, 56, 1923-1931.