Organic Chemistry Portal
Chemicals >> Reducing Agents

Ethanol


Recent Literature


The selective synthesis of Z-alkenes in alkyne semihydrogenation relies on the reactivity difference of the catalysts toward the starting materials and the products. In an Ir(III)-catalyzed semihydrogenation with EtOH as hydrogen source, an amine as additive is crucial to promote the alcoholysis. This catalytic system exhibits an unprecedented level of substrate scope, generality, and compatibility.
Z. Huang, Y. Wang, X. Leng, Z. Huang, J. Am. Chem. Soc., 2021, 143, 4809-4843.


A NCP-type pincer iridium complex enables an efficient, mild, chemoselective transfer hydrogenation of unactivated C-C multiple bonds with ethanol, forming ethyl acetate as the sole byproduct. A wide variety of alkenes, including multisubstituted alkyl alkenes, aryl alkenes, and heteroatom-substituted alkenes, as well as heteroarenes and internal alkynes, are suitable substrates.
Y. Wang, Z. Huang, X. Leng, H. Zhu, G. Liu, Z. Huang, J. Am. Chem. Soc., 2018, 140, 4417-4429.


A NCP-type pincer iridium complex enables an efficient, mild, chemoselective transfer hydrogenation of unactivated C-C multiple bonds with ethanol, forming ethyl acetate as the sole byproduct. A wide variety of alkenes, including multisubstituted alkyl alkenes, aryl alkenes, and heteroatom-substituted alkenes, as well as heteroarenes and internal alkynes, are suitable substrates.
Y. Wang, Z. Huang, X. Leng, H. Zhu, G. Liu, Z. Huang, J. Am. Chem. Soc., 2018, 140, 4417-4429.


Chiral iridium complexes ligated by anionic oxazoline-bearing NCP-type pincer ligands enable an asymmetric transfer hydrogenation (ATH) of diarylethenes using environmentally benign ethanol as the hydrogen donor. High enantioselectivities could be achieved for substrates bearing ortho-Me, ortho-Cl, or ortho-Br substituents on one of the aryl groups.
L. Qian, X. Tang, Z. Huang, Y. Wang, G. Liu, Z. Huang, Org. Lett., 2021, 23, 8978-8983.