Lithium tri-tert-butoxyaluminum hydride, LTBA
Recent Literature
A highly efficient in situ generation of the Schwartz reagent provides a
convenient method for the reduction of amides to aldehydes and the
regioselective hydrozirconation-iodination of alkynes and alkenes. These
single-step processes proceed in very short reaction time, show excellent
functional group compatibility, and use inexpensive and long-storage stable
reducing reagents.
Y. Zhao, V. Snieckus, Org. Lett., 2014,
16, 390-393.
In a sequential one-pot process for the conversion of sterically demanding
N,N-diisopropylamides to aldehydes, amides are activated with EtOTf to form
imidates, which are reduced with LiAlH(OR)3 [R = t-Bu, Et] to
give aldehydes by hydrolysis of the resulting hemiaminals. The non-nucleophilic
base 2,6-DTBMP remarkably improves reaction efficiency. The reaction tolerates
various reducible functional groups, including aldehyde and ketone.
P. Xiao, Z. Tang, K. Wang, H. Chen, Q. Guo, Y. Chu, L. Gao, Z. Song, J. Org. Chem., 2018, 83, 1687-1700.
