Organic Chemistry Portal
Chemicals >> Reducing Agents > Silanes

Triethoxysilane


Recent Literature


A zinc-catalyzed reduction of tertiary amides shows remarkable chemoselectivity and substrate scope tolerating ester, ether, nitro, cyano, azo, and keto substituents.
S. Das, D. Addis, S. Zhou, K. Junge, M. Beller, J. Am. Chem. Soc., 2010, 132, 1770-1771.


Transition-metal-free catalytic protocols for controlled reduction of amide functions using cheap and bench-stable hydrosilanes as reducing agents enable the selective reduction of unactivated C-O bonds in amides. By altering the hydrosilane and solvent, the C-N bonds selectively breaks via a deacylative cleavage.
W. Yao, L. He, D. Han, A. Zhong, J. Org. Chem., 2019, 84, 14627-14635.


A family of chiral iminophenyl oxazolinylphenylamines (IPOPA) ligands enables an efficient cobalt-catalyzed asymmetric hydrosilylation of simple ketones with a low catalyst loading of CoCl2 to afford chiral alcohols in good yields with high enantioselectivities.
X. Chen, Z. Lu, Org. Lett., 2016, 18, 4658-4661.


A highly regio- and enantioselective copper-catalyzed reductive hydroxymethylation of styrenes and 1,3-dienes with 1 atm of CO2 readily provides important chiral homobenzylic alcohols. Moreover, various 1,3-dienes were converted to chiral homoallylic alcohols with high yields and excellent regio-, enantio-, and Z/E-selectivities.
Y.-Y. Gui, N. Hu, X.-W. Chen, L-L. Liao, J.-H. Ye, Z. Zhang, J. Li, D.-G. Yu, J. Am. Chem. Soc., 2017, 139, 17011-17014.


An efficient rhodium-catalyzed method allows the preparation of aryltriethoxysilanes from arenediazonium tosylate salts. A new method for hydrodediazoniation has also been explored.
Z. Y. Tang, Y. Zhang, T. Wang, W. Wang, Synlett, 2010, 804-808.


A bimetallic catalyst system composed of a group 4 metallocene difluoride and palladium dichloride enables a reductive cross-coupling of alkynes and aryl halides to provide (E)-alkenes in the presence of a hydrosilane and NaF. This reaction proceeds via an in situ generated alkenyl metallocene intermediate derived from the group 4 metallocene difluoride.
K. Takahashi, H. Morishita, Y. Ogiwara, N. Sakai, J. Org. Chem., 2018, 83, 13734-13742.