Triisopropylsilane (TIPS)
Recent Literature
In a remote hydro-oxygenation of alkenes under palladium catalysis, both
terminal and internal alkenes are suitable to yield the corresponding linear
alcohols efficiently. A compatible SelectFluor/silane redox system plays an
essential role for the excellent chemo- and regioselectivities. The reaction
features a broad substrate scope and excellent functional group compatibility.
X. Li, X. Yang, P. Chen, G. Liu, J. Am. Chem. Soc.,
2022, 144, 22877-22883.
In a remote hydro-oxygenation of alkenes under palladium catalysis, both
terminal and internal alkenes are suitable to yield the corresponding linear
alcohols efficiently. A compatible SelectFluor/silane redox system plays an
essential role for the excellent chemo- and regioselectivities. The reaction
features a broad substrate scope and excellent functional group compatibility.
X. Li, X. Yang, P. Chen, G. Liu, J. Am. Chem. Soc.,
2022, 144, 22877-22883.
The merger of palladium catalysis with electrooxidation enables the
hydrofluorination of aryl-substituted alkenes ranging from styrenes to more
challenging α,β-unsaturated carbonyl derivatives to the corresponding benzylic
fluorides. This method can also be applied to the late-stage modification of
pharmaceutical derivatives.
A. Mandal, J. Jang, B. Yang, H. Kim, K. Shin, Org. Lett., 2023, 25,
195-199.
An efficient palladium-catalyzed remote hydrosulfonamidation (HSA) of
terminal and internal alkenes with a N-fluoro-N-(fluorosulfonyl)-carbamate
provides primary N-alkyl-N-(fluorosulfonyl)-carbamates. The
generated N-alkyl products can be directly converted to N-alkyl
sulfamides or amines via sulfur(VI) fluoride exchange reactions (SuFEx).
C. Hou, Z. Liu, L. Gan, W. Fan, L. Huang, P. Chen, Z. Huang, G. Liu, J. Am. Chem. Soc.,
2024, 146, 13536-13545.
