Further Information
Literature
Related Reactions
Aldol Addition
Robinson Annulation
Synthesis of enones
Aldol Condensation
In some cases, the adducts obtained from the Aldol Addition can easily be converted (in situ) to α,β-unsaturated carbonyl compounds, either thermally or under acidic or basic catalysis. The formation of the conjugated system is the driving force for this spontaneous dehydration. Under a variety of protocols, the condensation product can be obtained directly without isolation of the aldol.
The aldol condensation is the second step of the Robinson Annulation.
Mechanism of the Aldol Condensation
For the addition step see Aldol Addition
Recent Literature
An Efficient Method for the Selective Iodination of α,β-Unsaturated Ketones
Z. Wang, G. Yin, J. Qin, M. Gao, L. Cao, A. Wu, Synthesis, 2008,
3565-3568.
CBr4 as a Halogen Bond Donor Catalyst for the Selective Activation of
Benzaldehydes to Synthesize α,β-Unsaturated Ketones
I. Kazi, S. Guha, G. Sekar, Org. Lett.,
2017, 19, 1244-1247.
One-Pot Synthesis of β,β-Disubstituted α,β-Unsaturated Carbonyl Compounds
M. Sugiura, Y. Ashikari, M. Nakaijima, J. Org. Chem.,
2015,
80, 8830-8835.
Organocatalytic Asymmetric Reaction Cascade to Substituted Cyclohexylamines
J. Zhou, B. List, J. Am. Chem. Soc., 2007,
129, 7498-7499.