Further Information
Literature
Haloform Reaction
This reaction has been used in qualitative analysis to indicate the presence of a methyl ketone. The product iodoform is yellow and has a characteristic odour. The reaction has some synthetic utility in the oxidative demethylation of methyl ketones if the other substituent on the carbonyl groups bears no enolizable α-protons.
Mechanism of the Haloform Reaction
The reaction readily proceeds to completion because of the acidifying effect of the halogen substituents.
Recent Literature
Novel and Direct Transformation of Methyl Ketones or Carbinols to Primary
Amides by Employing Aqueous Ammonia
L. Cao, J. Ding, M. Gao, Z. Wang, J. Li, A. Wu, Org. Lett., 2009,
11, 3810-3813.
Iodine-Mediated Domino Protocol for the Synthesis of Benzamides from
Ethylarenes via sp3 C-H Functionalization
K. S. Vadagaonkar, H. P. Kalmode, S. Prakash, A. C. Chaskar,
Synlett, 2015, 26, 1677-1682.
Direct Transformation of Ethylarenes into Primary Aromatic Amides with N-Bromosuccinimide
and I2-Aqueous NH3
S. Shimokawa, Y. Kawagoe, K. Moriyama, H. Togo, Org. Lett., 2016, 18,
784-787.
ase-Catalyzed Deprotection of Aldehydes: A New Haloform Reaction
G. Abulipizi, K. Abuduwaili, S. Tian, M. Maihemuti, A. R. Abulikemu, Synthesis, 2024,
56, 482-486.