This reaction has been used in qualitative analysis to indicate the presence of a methyl ketone. The product iodoform is yellow and has a characteristic odour. The reaction has some synthetic utility in the oxidative demethylation of methyl ketones if the other substituent on the carbonyl groups bears no enolizable α-protons.
Mechanism of the Haloform Reaction
The reaction readily proceeds to completion because of the acidifying effect of the halogen substituents.
Iodine-Mediated Domino Protocol for the Synthesis of Benzamides from Ethylarenes via sp3 C-H Functionalization
K. S. Vadagaonkar, H. P. Kalmode, S. Prakash, A. C. Chaskar, Synlett, 2015, 26, 1677-1682.