Synthesis of β-amino ketones, aldehydes and derivatives
Upon exposure of enamides to aldehydes in the presence of a chiral NHC catalyst, C-C bond formation provides N-protected amines, bearing a quaternary carbon center, in good yields and with high enantioselectivities.
J. Wu, C. Zhao, J. Wang, J. Am. Chem. Soc., 2016, 138, 4706-4709.