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Synthesis of β-amino ketones, aldehydes and derivatives


Recent Literature

The combination of Ni and HAT photocatalysis successfully enables the ring opening of N-tosyl styrenyl aziridines with aldehydes to provide a variety of β-amino ketones with complete regiocontrol. Whereas aldehydes are converted into acyl radicals by TBADT under irradiation, the Ni catalyst is engaged in the ring opening of aziridines and the following carbon-carbon bond-forming step.
P. Fan, Y. Jin, J. Liu, R. Wang, C. Wang, Org. Lett., 2021, 23, 7364-7369.

Upon exposure of enamides to aldehydes in the presence of a chiral NHC catalyst, C-C bond formation provides N-protected amines, bearing a quaternary carbon center, in good yields and with high enantioselectivities.
J. Wu, C. Zhao, J. Wang, J. Am. Chem. Soc., 2016, 138, 4706-4709.