Categories: C-C Bond Formation > Heteroatom-containing Molecules, Chains > Trifluoromethylation
Synthesis of propargylic trifluoromethanes
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A palladium-catalyzed decarboxylative coupling reaction of aryl alkynyl carboxylic
acids and ICH2CF3 enables a trifluoroethylation of alkynes
in good yields. The catalytic system showed high functional group tolerance.
J. Hwang, K. Park, J. Choe, H. Min, K. H. Song, S. Lee, J. Org. Chem., 2014,
79, 3267-3271.