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Categories: C-C Bond Formation > Heteroatom-containing Molecules, Chains > Trifluoromethylation

Synthesis of propargylic trifluoromethanes

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A palladium-catalyzed decarboxylative coupling reaction of aryl alkynyl carboxylic acids and ICH2CF3 enables a trifluoroethylation of alkynes in good yields. The catalytic system showed high functional group tolerance.
J. Hwang, K. Park, J. Choe, H. Min, K. H. Song, S. Lee, J. Org. Chem., 2014, 79, 3267-3271.