Organic Chemistry Portal
Reactions > Organic Synthesis Search

Categories: C-C Bond Formation >

Nitrogen-containing molecules

Synthesis of          
Amines 1,2-Diamines    
Hydrazines          
1,2-Amino
Alcohols
1,3-Amino
Alcohols
     
Amino
Ketones
     
α-Amino Acids
and Derivatives
β-Amino Acids
and Derivatives
Imines Enamines Diazo Compounds  
Oximes Amidines      
Nitriles    
Cyanohydrins Aroyl cyanides
Alkanoyl cyanides
   
Aminonitriles      
Nitro compounds    


Recent Literature


Potassium trifluoro(organo)borates, which are highly stable and easily prepared organoboron derivatives, were able to react with various dehydroamino esters to alanine derivatives in good to high yields. This reaction, catalyzed by rhodium complexes, tolerates a great variety of amino protecting groups.
L. Navarre, S. Darses, J.-P. Genet, Eur. J. Org. Chem., 2004, 69-73.


β-Functionalized sulfonamides were produced in good yields by the regioselective ring opening of N-tosylaziridines with trimethylsilylated nucleophiles, catalyzed by N,N,N',N'-tetramethylethylenediamine (TMEDA).
S. Minakata, Y. Okada, Y. Oderaotoshi, M. Komatsu, Org. Lett., 2005, 7, 3509-3512.