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Synthesis of 1,3-amino alcohols

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A Ni-catalyzed asymmetric reductive coupling of 2-aza-butadiene with aldehydes provides chiral γ-secondary amino alcohols. This transformation offers good enantioselectivity and tolerance to various functional groups. Notably, this reaction delivers β-siloxyl imine, an aza-aldol-type product which is difficult to access by conventional methods.
L. Yang, W. Shang, L. Zhang, X. Zhang, Org. Lett., 2022, 24, 7763-7768.