Categories: C-C Bond Formation > Nitrogen-containing molecules >

Synthesis of α-Aminonitriles

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Recent Literature

Depending on the Lewis base catalyst, a Michael addition of α-aminonitriles to simple activated alkenes provides functionalized γ-amino acid esters or γ-lactams. The scope, versatility, and efficiency of the methods were demonstrated.
Z.-Y. He, H.-C. Jang, L.-S. Teng, Z.-L. Wei, W.-W. Liao, Synthesis, 2021, 53, 1833-1841.