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Synthesis of β-Amino Acids and Derivatives by Carboxylation


Recent Literature

In a palladium-catalyzed intermolecular aminocarbonylation of alkenes, the use of hypervalent iodine reagent can accelerate the reaction. The current transformation presents a convenient method to generate β-amino acid derivatives from simple alkenes.
J. Cheng, X. Qi, M. Li, P. Chen, G. Liu, J. Am. Chem. Soc., 2015, 137, 2480-2483.

A Ni-catalyzed reductive carboxylation of N-substituted aziridines with CO2 at atmospheric pressure provides β-amino acids, important building blocks with considerable potential as peptidomimetics. The protocol offers mild conditions, experimental ease, and exquisite chemo- and regioselectivity.
J. Davies, D. Janssen-Müller, D. P. Zimin, C. S. Day, T. Yanagi, J. Elfert, R. Martin, J. Am. Chem. Soc., 2021, 143, 4949-4954.