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Synthesis of Hydrazones


Recent Literature

In a visible-light-induced Pd-catalyzed stereoselective synthesis of alkylated ester hydrazones, a generation of a nucleophilic carbon-centered radical from alkyl bromide, iodide, or redox-active ester, is followed by its addition to hydrazone, and a subsequent desaturation by palladium. A a reaction between 1,3-dihalides and glyoxylate-derived hydrazone delivers tetrahydropyridazines.
N. Kvasos, V. Gevorgyan, Org. Lett., 2022, 24, 4176-4181.