Categories: C-C Bond Formation > Sulfur-containing molecules >
Synthesis of Sulfones
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Recent Literature
In a palladium catalyzed Negishi-type α-arylation of sulfones and
sulfonamides with a broad range of aryl bromides, the substrates are
selectively metalated in situ with tmp·ZnCl·LiCl base and cross-coupled in
the presence of a catalyst system that is generated from Pd(dba)2
and XPhos.
T. Knauber, J. Tucker, J. Org. Chem.,
2016,
81, 5636-5648.
Ni-catalyzed stereoconvergent Negishi arylations and alkenylations of
racemic α-bromosulfonamides and -sulfones furnish cross-coupling product in
very good ee and yield for an array of reaction partners. Mechanistic
studies are consistent with the generation of a radical intermediate.
J. Choi, P. Martín-Gago, G. C. Fu, J. Am. Chem. Soc., 2014,
136, 12161-12165.
Selectfluor-promoted cascade cyclizations and cross-coupling reactions provide
either 2,5-diacylthiophenes or β-acyl allylic methylsulfones from readily
available starting materials by simple solvent modification. The transformations
offer excellent chemoselectivity, and good functional group tolerance.
H. Lu, J. Chen, W. Zhou, L. Peng, S.-F. Yin, N. Kambe, R. Qiu, Org. Lett., 2023, 25,
389-394.