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Synthesis of 1,2-difluoroalkanes
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Recent Literature
Iodine catalyzes a simple and practical difluorination reaction of alkenes. The
reaction can be applied to many aliphatic and aromatic alkenes bearing
synthetically useful functional groups, such as ester, amide, hydroxy, and aryl
groups.
T. Kitamura, J. Oyamada, M. Higashi, Y. Kishikawa, J. Org. Chem., 2024, 89,
5896-5900.
A catalytic, vicinal difluorination of olefins displays broad functional group
tolerance, using inexpensive p-iodotoluene as the catalyst. Preliminary
efforts toward the development of an enantioselective variant are reported.
I. G. Molnár, R. Gilmour, J. Am. Chem. Soc., 2016,
138, 5004-5007.