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Synthesis of 1,2-difluoroalkanes

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Iodine catalyzes a simple and practical difluorination reaction of alkenes. The reaction can be applied to many aliphatic and aromatic alkenes bearing synthetically useful functional groups, such as ester, amide, hydroxy, and aryl groups.
T. Kitamura, J. Oyamada, M. Higashi, Y. Kishikawa, J. Org. Chem., 2024, 89, 5896-5900.


A catalytic, vicinal difluorination of olefins displays broad functional group tolerance, using inexpensive p-iodotoluene as the catalyst. Preliminary efforts toward the development of an enantioselective variant are reported.
I. G. Molnár, R. Gilmour, J. Am. Chem. Soc., 2016, 138, 5004-5007.