Categories: C-F Bond Formation >
Synthesis of propargyl fluorides
Recent Literature
An isothiourea-catalyzed fluorination of alkynyl-substituted acetic acids
provides a broad range of optically active tertiary α-alkyl fluorides in high
enantioselectivity (up to 97% ee). Furthermore, this methodology can be scaled
up to a Gram scale without loss of enantioselectivity.
S. Yuan, W.-H. Zheng, J. Org. Chem., 2022, 87,
713-720.
Related
A photoinduced copper-catalyzed monofluoroalkylation of alkynes with readily
available monofluoroalkyl triflates provides valuable propargyl fluorides in
good yields under mild conditions. This C-C bond formation avoids the use of
highly toxic fluorination reagents. Preliminary mechanistic studies reveal that
a ligand-matched alkynyl copper complex might be the key photoactive substance.
D.-D. Hu, C. Li, Q. Gao, T.-M. Nie, K.-F. Zhang, B.-B. Wu, Y. Li, X.-S. Wang, Org. Lett., 2023, 25,
4514-4519.