Categories: C-H Bond Formation >
Hydrogenolysis of cyclopropanes
The Zn-AcOH reductive system enables a regioselective and rapid ring-opening of donor-acceptor cyclopropanes. 2-(Het)Arylcyclopropane-1,1-diesters as well as donor-acceptor cyclopropanes with other types of electron-withdrawing activating groups provides γ-substituted propyl-1,1-diesters, ketoesters, cyanoesters, cyanoamides, dinitriles, etc., which are not readily accessible with alternative methods.
K. L. Ivanov, E. V. Villemson, G. V. Latyshev, S. I. Bezzubov, A. G. Majouga, M. Ya. Melnikov, E. M. Budynina, J. Org. Chem., 2017, 82, 9537-9549.