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C-H Bond Formation


Decarboxylations, Decarbonylations

Dehalogenations and other Reductive Cleavages









Synthesis of 1,4-cyclohexadienes

Reduction of aromatic compounds

Reduction of alkenes

Reduction of alkynes

Semireduction of alkynes

Reduction of α,β-unsaturated compounds

Reduction of epoxides

Hydrogenolysis of cyclopropanes

Reduction of carboxyl compounds

Reduction of acid chlorides

Reduction of esters

Rection of nitriles

Reduction of amides

Reduction of amides

Reduction of thioamides

Recent Literature

The preparation of alkenyl halides of any length from inexpensive starting reagents is reported. Standard organic transformations were used to prepare straight-chain α-olefin halides in excellent overall yields with no detectable olefin isomerization and full recovery of any unreacted starting material.
T. W. Baughman, J. C. Sworen, K. B. Wagener, Tetrahedron, 2004, 60, 10943-10948.

Addition of in situ generated Schwartz reagent to widely available isocyanates enables a chemoselective, high-yielding, and versatile synthesis of variously functionalized formamides. The reaction tolerates the presence of sensitive functionalities (esters, nitro groups, nitriles, alkenes).
V. Pace, K. de la Vega-Hernández, E. Urban, T. Langer, Org. Lett., 2016, 18, 2750-2753.