Categories: C-H Bond Formation >
Reduction of acid chlorides
Name Reactions
Recent Literature
The use of hydrosilanes as reducing agents in the presence of a palladium
catalyst enables an efficient synthesis of aldehydes from acid chlorides. A
simple mixture of commercially available Pd(dba)2 and Mes3P
catalyzed the reduction of various acid chlorides including aliphatic acid
chlorides and α,β-unsaturated acid chlorides to the corresponding aldehydes in
good to high yields under mild reaction conditions.
T. Fujihara, C. Cong, T. Iwai, J. Terao, Y. Tshuji, Synlett, 2012, 23,
2389-2392.
Polymethylhydrosiloxane (PMHS) under Pd(0) catalysis can efficiently reduce
aryl acid chlorides to their corresponding aldehydes in the presence of
fluoride without requiring an additional reductant.
K. Lee, R. E. Maleczka, Jr., Org. Lett.,
2006,
8, 1887-1888.