Categories: C-H Bond Formation >
Reduction of thioamides to amines
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Recent Literature
4-Dimethylaminopyridine-BH3 as the boryl radical precursor promotes a
desulfurizative reduction to access organic amines in the presence of PhSH as
the polarity reversal catalyst. Alternatively a N-heterocyclic carbene-BH3
as the boryl radical precursor and sterically bulky Ph3CSH as
catalyst can be used for annulation of unsaturated thioamides allowing for the
construction of N-heterocyclic and carbocyclic skeletons.
Y.-J. Yu, F.-L. Zhang, J. Cheng, J.-H. Hei, W.-T. Deng, Y.-F. Wang, Org. Lett.,
2018, 20, 24-27.