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Synthesis of γ-amino alcohols

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An aza-Michael addition-asymmetric transfer hydrogenation tandem process provides chiral γ-secondary amino alcohols in high yields with high enantioselectivities. This one-pot tandem process involves an aza-Michael addition of aryl-substituted enones and amines to form aryl-substituted γ-secondary amino ketones, followed by a Ru-catalyzed asymmetric transfer hydrogenation.
L. Wu, R. Jin, L. Li, X. Hu, T. Cheng, G. Liu, Org. Lett., 2017, 19, 3047-3050.