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Synthesis of γ-amino alcohols


Recent Literature

An aza-Michael addition-asymmetric transfer hydrogenation tandem process provides chiral γ-secondary amino alcohols in high yields with high enantioselectivities. This one-pot tandem process involves an aza-Michael addition of aryl-substituted enones and amines to form aryl-substituted γ-secondary amino ketones, followed by a Ru-catalyzed asymmetric transfer hydrogenation.
L. Wu, R. Jin, L. Li, X. Hu, T. Cheng, G. Liu, Org. Lett., 2017, 19, 3047-3050.

Intramolecular C-H amination using commercial Rh-catalysts, PhI(OAc)2, and MgO offers a practical solution for the controlled oxidation of saturated C-H bonds. Reactions of sulfamates with 2 mol % Rh2(OAc)4, PhI(OAc)2, and MgO yield selectively six-membered ring oxathiazinanes. These heterocycles can serve as precursors for 1,3-amino alcohols, β-amino acids, and numerous other amine derivatives.
C. G. Espino, P. M. Wehn, J. Chow, J. Du Bois, J. Am. Chem. Soc., 2001, 123, 6935-6936.