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Synthesis of 1,2-Diazides

Recent Literature


CHAMPO, a new aminoxyl radical catalyst, enables an electrochemical diazidation of a broad range of alkenes in good yields. Mediated by an anodically generated charge-transfer complex in the form of CHAMPO-N3, radical diazidation was achieved without the need for a transition metal catalyst or a chemical oxidant.
J. C. Siu, J. B. Parry, S. Lin, J. Am. Chem. Soc., 2019, 141, 2825-2831.


A scalable Cu-electrocatalytic alkene diazidation reaction with 0.02 mol % of copper(II) acetylacetonate as the precatalyst without exogenous ligands is compatible with a broad range of functional groups, and applicable to the diazidation of α,β-unsaturated carbonyl compounds and mono-, di-, tri-, and tetrasubstituted unactivated alkenes.
C.-Y. Cai, Y.-T. Zheng, J.-F. Li, H.-C. Xu, J. Am. Chem. Soc., 2022, 144, 11980-11985.


An azidoiodine(III) reagent is used as an efficient azide radical source for efficient copper-catalyzed oxyazidation and diazidation of styrenes in good yields. Various synthetically useful functional groups are tolerated under the mild reaction conditions.
M.-Z. Lu, C.-Q. Wang, T.-P. Loh, Org. Lett., 2015, 17, 6110-6113.