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Synthesis of ketene aminals

Recent Literature

A Ni(OTf)2-catalyzed hydroamination of ynamides with secondary amines provides substituted ethene-1,1-diamine compounds in good yields with high regioselectivities. This protocol features a broad substrate scope of secondary aryl amines and good functional group tolerance for ynamides.
X.-D. Nie, X.-L. Han, J.-T. Sun, C.-M. Si, B.-G. Wei, G.-Q. Lin, J. Org. Chem., 2021, 86, 3433-3443.

A copper-catalyzed four-component formal oxyaminalization of alkenes with Togni's reagent and amines in the presence of molecular oxygen as both the oxidant and oxygen source efficiently provides a range of structurally diverse α-oxoketene aminals. This simple procedure offers excellent functional group tolerance, broad substrate scope, and mild conditions.
L. Wang, C. Qi, T. Guo, H. Jiang, Org. Lett., 2019, 21, 2223-2226.

A silver-based catalyst promotes a syn-selective hydroamination of electron-rich alkynes with either secondary amides or carbamates. This method is efficient for the synthesis of various synthetically useful silyl ketene aminals. The mechanism is discussed.
J. Sun, S. A. Kozmin, Angew. Chem. Int. Ed., 2006, 45, 4991-4993.