Categories: C-N Bond Formation > Synthesis of substituted N-heterocycles >
N-alkylation
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A simple and efficient method enables the synthesis of N-alkynylheteroarenes
from 1,1-dibromo-1-alkenes via a copper-catalyzed cross-coupling reaction. Good
yields and functional-group tolerance were obtained with TMEDA as ligand using
imidazole and benzimidazole substrates in dioxane.
M.-G. Wang, J. Wu, Z.-C. Shang, Synlett, 2012, 23,
589-594.