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Synthesis of isothiocyanates


Recent Literature

A ZnI2-catalyzed addition of ammonium thiocyanate to olefins in the presence of 4-toluenesulfonic acid and tetrabutylammonium iodide proceeds by a Markovnikov-type process and a radical isomerization to provide the corresponding isothiocyanates selectively and in good yields.
N. Taniguchi, Synlett, 2023, 34, 73-76.

An electrochemical benzylic isothiocyanation provides isothiocyanate derivatives in a highly chemo- and site-selective manner under external oxidant-free conditions. The method exhibits high functional group compatibility and is suitable for late-stage functionalization of bioactive molecules.
S. Zhang, Y. Li, T. Wang, M. Li, L. Wen, W. Gup, Org. Lett., 2022, 24, 1742-1746.

A novel and highly selective method uses triphenylphosphine, diethylazodicarboxylate and NH4SCN for the conversion of alcohols, thiols, carboxylic acids, silyl ethers, and silyl carboxylates to their corresponding thiocyanates.
N. Iranpoor, H. Firouzabadi, B. Akhlaghinia, R. Azadi, Synthesis, 2004, 92-96.