Organic Chemistry Portal >
Reactions > Organic Synthesis Search

Categories: C-N Bond Formation >

Synthesis of isothiocyanates


Recent Literature

An electrochemical benzylic isothiocyanation provides isothiocyanate derivatives in a highly chemo- and site-selective manner under external oxidant-free conditions. The method exhibits high functional group compatibility and is suitable for late-stage functionalization of bioactive molecules.
S. Zhang, Y. Li, T. Wang, M. Li, L. Wen, W. Gup, Org. Lett., 2022, 24, 1742-1746.

A novel and highly selective method uses triphenylphosphine, diethylazodicarboxylate and NH4SCN for the conversion of alcohols, thiols, carboxylic acids, silyl ethers, and silyl carboxylates to their corresponding thiocyanates.
N. Iranpoor, H. Firouzabadi, B. Akhlaghinia, R. Azadi, Synthesis, 2004, 92-96.