Categories: C-N Bond Formation >
Synthesis of isothiocyanates
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Recent Literature
An electrochemical benzylic isothiocyanation provides isothiocyanate
derivatives in a highly chemo- and site-selective manner under external
oxidant-free conditions. The method exhibits high functional group compatibility
and is suitable for late-stage functionalization of bioactive molecules.
S. Zhang, Y. Li, T. Wang, M. Li, L. Wen, W. Gup, Org. Lett.,
2022, 24, 1742-1746.
A novel and highly selective method uses triphenylphosphine,
diethylazodicarboxylate and NH4SCN for the conversion of
alcohols, thiols, carboxylic acids, silyl ethers, and silyl carboxylates to
their corresponding thiocyanates.
N. Iranpoor, H. Firouzabadi, B. Akhlaghinia, R. Azadi, Synthesis, 2004,
92-96.
