Categories: C-N Bond Formation >
Synthesis of sulfinamides
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Recent Literature
In the presence of Pd2(dba)3, tBuXPhos, NaOH, and a
small amount of water, the C-N cross coupling of chiral tert-butanesulfinamide
and aryl halides was accomplished to give N-aryl tert-butanesulfinamide
without racemization, and the coupling of racemic p-toluenesulfinamide
smoothly afforded N-aryl p-toluenesulfinamides. Addition of a
small amount of water to the catalytic system was of importance to obtain high
yields.
X. Sun, X. Tu, C. Sai, X. Zhang, B. Zhang, Q. Zeng, J. Org. Chem., 2012,
77, 4454-4459.