Categories: C-N Bond Formation >
Synthesis of thiocarbamates
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Recent Literature
A facile and efficient synthesis of isothiocyanates involves the reaction of
amines with phenyl chlorothionoformate in the presence of solid sodium hydroxide
by either a one-pot process or a two-step approach. The one-pot process is
useful for preparing alkyl and electron-rich aryl isothiocyanates, whereas the
two-step approach is more versatile.
Z.-Y. Li, H.-Z. Ma, C. Han, H.-T. Xi, Q. Meng, X. Chen, X.-Q. Sun, Synthesis, 2013, 45,
1667-1674.