Organic Chemistry Portal
Reactions > Organic Synthesis Search

Categories: C-O Bond Formation > Synthesis of carboxylic acids >

Synthesis of carboxylic acids by hydrolysis or saponification


Name Reactions

Favorsky Reaction

Protecting Groups

Benzyl esters

Recent Literature

N,N-diarylammonium pyrosulfate efficiently catalyzes the hydrolysis of esters under organic solvent-free conditions. This reverse micelle-type method is successfully applied to the hydrolysis of various esters without the decomposition of base-sensitive moieties and without any loss of optical purity for α-heterosubstituted carboxylic acids.
Y. Koshikari, A. Sakakura, K. Ishihara, Org. Lett., 2012, 14, 3194-3197.

An interesting example of a selective deprotection of tert-butyl esters is reported.
E. Marcantoni, M. Massaccesi, E. Torregiani, G. Bartoli, M. Bosco, L. Sambri, J. Org. Chem, 2001, 66, 4430-4432.