Categories: C-O Bond Formation >
Synthesis of ortho esters
Recent Literature
Primary, secondary and electron-deficient tertiary alcohols react rapidly with
ketene dimethyl acetal to form mixed ortho esters, without catalysts and under
solvent-free conditions. 1,2-Diols yield bis(mixed ortho esters), rather than
cyclic ortho esters.
K. L. Cosgrove, R. P. McGeary, Synlett, 2008,
2425-2428.
A wide variety of functionalized orthoesters can be prepared under mild and green electrochemical conditions from
easily accessible dithiane derivatives.
A. D. Garcia, M. C. Leech, A. Petti, C. Denis, I. C. A. Goodall, A. P. Dobbs, K.
Lam,
Org. Lett., 2020, 22, 3875-3878.
Bicyclo orthoesters and amide acetals were prepared from the corresponding
triols or diethanolamines using α,α-difluoroalkylamines. The reactions proceeded
under mild conditions.
S. Tange, T. Fukuhara, S. Hara, Synthesis, 2008,
3219-3222.