Organic Chemistry Portal
Reactions > Organic Synthesis Search

Categories: C-O Bond Formation >

Synthesis of ortho esters

Recent Literature

Primary, secondary and electron-deficient tertiary alcohols react rapidly with ketene dimethyl acetal to form mixed ortho esters, without catalysts and under solvent-free conditions. 1,2-Diols yield bis(mixed ortho esters), rather than cyclic ortho esters.
K. L. Cosgrove, R. P. McGeary, Synlett, 2008, 2425-2428.

Bicyclo orthoesters and amide acetals were prepared from the corresponding triols or diethanolamines using α,α-difluoroalkylamines. The reactions proceeded under mild conditions.
S. Tange, T. Fukuhara, S. Hara, Synthesis, 2008, 3219-3222.