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Synthesis of disulfides
Recent Literature
In an efficient, copper-catalyzed electrophilic persulfuration reaction leading
to unsymmetrical disulfides and polysulfides, various nucleophiles, including
aryl boronic acids, β-keto esters, and thiols, can be used as substrates. This
method offers simple and practical conditions, and general scope.
R. Sanz, A. Martinez, J. M. Alvarez-Gutierrez, F. Rodriquez, Eur. J. Org.
Chem., 2006, 1383-1386.
A transition metal/ligand-free disulfuration of anilines can be performed
under mild conditions and exhibits broad scope across the aniline substrate and
disulfur transfer reagent classes (dithiosulfonate or tetrasulfide). This
reaction can be considered as a reductive disulfuration variation of the classic
Sandmeyer reaction.
S. Chen, S. Cao, C. Liu, B. Wang, X. Ren, H. Huang, Z. Peng, X. Wang, Org. Lett., 2021, 23,
7428-7433.
Alkyl and aryl radicals generated thermally or photochemically underwent
substitution on readily prepared dialkyl, diaryl, and diacyl tetrasulfides to
yield the corresponding disulfides in good to excellent yields.
Z. Wu, D. A. Pratt, J. Am. Chem. Soc.,
2020, 142, 10284-10290.
Acetyl masked disulfide nucleophiles can be used as disulfide source to react
with a wide range of epoxides, affording various β-acetoxy or β-hydroxyl
disulfides in good yields with high regioselectivity. This simple
transition-metal-free method offers high atom economy and scalability.
Y. Yu, X. Zhou, J. Wang, Y. Jiang, H. Cao, Org. Lett., 2023, 25,
8937-8941.