Categories: C-S Bond Formation
Synthesis of N,S-acetals
Recent Literature
Enantioenriched N,S-acetals can be prepared using chiral BINOL phosphoric
acids. The reaction combines electron-rich and electron-deficient aromatic N-acyl
imines with broad range of aliphatic and aromatic thiols to generate products in
excellent yield and enantioselectivity. The addition reaction could also be
achieved with an exceptional substrate to catalyst (S/C) molar ratio.
G. K. Ingle, M. G. Mormino, L. Wojtas, J. C. Antilla, Org. Lett., 2011,
13, 4762-4765.