Synthesis of N,S-acetals

Recent Literature

Enantioenriched N,S-acetals can be prepared using chiral BINOL phosphoric acids. The reaction combines electron-rich and electron-deficient aromatic N-acyl imines with broad range of aliphatic and aromatic thiols to generate products in excellent yield and enantioselectivity. The addition reaction could also be achieved with an exceptional substrate to catalyst (S/C) molar ratio.
G. K. Ingle, M. G. Mormino, L. Wojtas, J. C. Antilla, Org. Lett., 2011, 13, 4762-4765.