Synthesis of propargylic sulfones
A catalyst-free, environmentally benign protocol provides propargylic sulfones containing highly congested carbon centers from easily accessible alcohols and sulfinic acids with water as the only byproduct via an in situ dehydrative cross-coupling process.
Y. Liu, P. Xie, Z. Sun, X. Wo, C. Gao, W. Fu, T.-P. Loh, Org. Lett., 2018, 20, 5353-5356.
In the absence of external catalysts and additives, a broad range of benzylic and allylic alcohols react with various sulfinyl chlorides to afford structurally diversified benzylic and allylic sulfones in moderate to excellent yields. A catalysis with byproduct HCl is involved in this new protocol.
H.-H. Li, D.-J. Dong, Y.-H. Jin, S.-K. Tian, J. Org. Chem., 2009, 74, 9501-9504.