Categories: C-Si Bond Formation > Silanes
Synthesis of alkynylsilanes
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NaOH and KOH catalyze a mild, scalable, and chemoselective catalytic
cross-dehydrogenative C-H bond functionalization protocol for the construction
of C(sp)-Si bonds in a single step. The scope of the alkyne and hydrosilane
partners is substantial, providing an entry point into various organosilane
building blocks.
A. A. Toutov, K. N. Betz, D. P. Schuman, W.-B. Liu, A. Fedorov, B. M. Stoltz, R.
H. Grubbs, J. Am. Chem. Soc., 2017,
139, 1668-1674.
A rapid and high-yielding silylation of terminal alkynes employing TMSOTf and
catalytic quantities of Zn(OTf)2 works well for a variety of substrates
including reactive esters.
R. J. Rahaim, Jr., J. T. Shaw, J. Org. Chem., 2008,
73, 2912-2915.
Various alkynylsilanes were efficiently prepared via zinc halides-mediated direct silylation of terminal alkynes with aminosilanes. Base- and nucleophile-sensitive functionalities were tolerated under the reaction conditions. The electrophilic character of this transformation is supported by initial mechanistic studies.
A. A. Andreev, V. V. Konshin, N. V. Komarov, M. Rubin, C. Brouwer, V. Gevorgyan, Org. Lett., 2004, 6, 421-424.
