Categories: C=C Bond Formation >
Synthesis of allenes by semireduction
An efficient enantio- and chemoselective copper hydride catalyzed semireduction of conjugated enynes provides 1,3-disubstituted allenes using water as the proton source. This protocol tolerates various functional groups including keto, ester, amino, halo, and hydroxyl groups.
L. Bayeh-Romero, S. L. Buchwald, J. Am. Chem. Soc., 2019, 141, 13788-13794.