Categories: C=N Bond Formation >
Synthesis of hydrazones
A catalytic acceptorless dehydrogenative coupling of arylhydrazines and alcohols enables a direct synthesis of arylhydrazones with complete selectivity for arylhydrazones without N-alkylated byproducts. This process provides a new horizon for the development of catalytic acceptorless dehydrogenative coupling reactions.
F. Li, C. Sun, N. Wang, J. Org. Chem., 2014, 79, 8031-8039.
N-tert-butyldimethylsilylhydrazone (TBSH) derivatives from carbonyl-containing compounds serve as superior alternatives to simple hydrazones in Wolff-Kishner-type reduction reactions, in the Barton vinyl iodide preparation, in the synthesis of vinyl bromides, and in the synthesis of gem-diiodides, gem-dibromides, and gem-dichlorides.
M. E. Furrow, A. G. Myers, J. Am. Chem. Soc., 2004, 126, 5436-5445.
A Michael addition of amines and hydrazines to nitrostyrenes provides N-alkyl/aryl substituted benzyl imines and N-methyl/phenyl substituted benzyl hydrazones via a retro-aza-Henry-type process under mild, noncatalytic conditions. The method can be used for the synthesis of biologically important N-methyl pyrazoles in a one-pot manner, simple starting with the corresponding nitrostyrenes and the methylhydrazine.
M. G. Kallitsakis, P. D. Tancini, M. Dixit, G. Mpourmpakis, I. N. Lykakis, J. Org. Chem., 2018, 83, 1176-1184.
A mild diazenylation of active methylene compounds and N-heterocyclic compounds with arylhydrazine hydrochlorides is mediated by iodine under basic aerobic conditions. The reaction could be executed either under heating or in the presence of blue LED light.
D. S. Barak, S. U. Dighe, I. Avasthi, S. Batra, J. Org. Chem., 2018, 83, 3361-3366.