Categories: C=N Bond Formation >
Synthesis of isoureas
A three-component coupling reaction of alcohols or thiols with N,N-dibromoarylsulfonamides and isonitrile and in the presence of K2CO3 provides both isoureas and isothioureas in very good yields. This metal-free process proceeds via carbodiimide intermediate at room temperature within a very short reaction time.
D. Mishra, P. Phukan, J. Org. Chem., 2021, 86, 17581-17593.
A highly efficient rhodium-catalyzed tandem reaction of isocyanides with azides and various oxygen nucleophiles provides various N-sulfonyl/acylisoureas with broad substrate scope in an atom-economical manner.
X.-B. Bu, Z.-X. Zhang, Q.-Q. Peng, X. Xu, Y.-L. Zhao, J. Org. Chem., 2019, 84, 53-59.