Categories: C=N Bond Formation >
Synthesis of isoureas
Related |
Recent Literature
A three-component coupling reaction of alcohols or thiols with N,N-dibromoarylsulfonamides
and isonitrile and in the presence of K2CO3 provides both isoureas and
isothioureas in very good yields. This metal-free process proceeds via
carbodiimide intermediate at room temperature within a very short reaction time.
D. Mishra, P. Phukan, J. Org. Chem., 2021, 86,
17581-17593.
A highly efficient rhodium-catalyzed tandem reaction of isocyanides with azides and
various oxygen nucleophiles provides various N-sulfonyl/acylisoureas
with broad substrate scope in an atom-economical manner.
X.-B. Bu, Z.-X. Zhang, Q.-Q. Peng, X. Xu, Y.-L. Zhao, J. Org. Chem., 2019, 84,
53-59.