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Synthesis of aldehydes by isomerisations

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An operationally simple palladium-catalyzed isomerization of highly substituted allylic alcohols and alkenyl alcohols is applicable to a broad range of substrates and displays a wide functional group tolerance. Carbonyl compounds can usually be isolated in high chemical yield. Experimental and computational mechanistic investigations provide evidence for a chain-walking process consisting of repeated migratory insertion/β-H elimination sequences.
E. Larionov, L. Lin, L. Guénée, C. Mazet, J. Am. Chem. Soc., 2014, 136, 16882-16894.


DABCO is a suitable catalyst for the isomerization of γ-hydroxy enones in an organocatalytic redox isomerization strategy for the synthesis of 1,4-ketoaldehydes in high yields.
K. Mondal, B. Mondal, S. C. Pan, J. Org. Chem., 2016, 81, 4835-4840.