Categories: C=O Bond Formation > Synthesis of ketones
Synthesis of α-amino ketones and aldehydes
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Recent Literature
An oxo-amination process with readily available N-bromosuccinimide (NBS)
and secondary amines as N-sources and dimethyl sulfoxide (DMSO) as the
oxidant provides amino alcohols in a single step. For the first time, the
formation of reactive Me2S+-O-Br species generated by the
interaction of NBS with DMSO has been proven.
P. K. Prasad, R. N. Reddi, A. Sudalai, Org. Lett., 2016, 18,
500-503.
IBX has been utilized for the oxidation of various epoxides and aziridines as
their β-cyclodextrin complexes in water to afford α-hydroxyketones and α-aminoketones
in good yields, respectively.
K. Surendra, N. S. Krishnaveni, M. A. Reddy, Y. V. D. Nageswar, K. R. Rao, J.
Org. Chem., 2003, 68, 9119-9121.
A rapid and effective reaction of 3-aryl-2H-azirines and highly
substituted 2-Me/Ph-3-aryl-2H-azirines with various carboxylic acids
provides N-acylated α-aminoketone derivatives under ambient air within 10
min at room temperature.
A. De, S. Santra, G. V. Zyryanov, A. Majee,
Org. Lett., 2020, 22, 3875-3878.
