Categories: C=S Bond Formation >
Synthesis of Thioureas
Related: |
Recent Literature
The combination of sulfur and chloroform enables an efficient and practical
synthesis of a thiocarbonyl surrogate. Various thiocarbamides and
oxazolidinethiones have been synthesized, including chiral thiourea catalysts
and chiral oxazolidinethione auxiliaries with high selectivity.
W. Tan, J. Wei, X. Jiang, Org. Lett.,
2017, 19, 2166-2169.
A completely atom-economic reaction of isocyanides with aliphatic amines in the
presence of elemental sulfur proceeds efficiently at (nearly) ambient
temperature to produce thioureas in excellent yields.
T. B. Nguyen, L. Ermolenko, A. Al-Mourabit, Synthesis, 2014, 46,
3172-3179.