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Synthesis of Isonitriles

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Treatment of N-substituted formamides with chlorophosphate compounds and tertiary amine bases produced the corresponding isocyanides in high yields. This method can be used to prepare various alkyl and aryl isocyanides.
G. Kobayashi, T. Saito, Y. Kitano, Synthesis, 2011, 3225-3234.


Treatment of N-substituted formamides with triphenylphosphine and molecular iodine quickly produces the corresponding isocyanides in high yields under ambient conditions in the presence of a tertiary amine. This convenient synthetic procedure employs readily available and low-cost reagents and mild reaction conditions for the synthesis of various alkyl and aryl isocyanides.
X. Wang, Q.-G. Wang, Q.-L. Luo, Synthesis, 2015, 47, 49-54.


A facile conversion of both aliphatic and aromatic formamides to isonitriles under very mild conditions and microwave irradiation is described.
A. Porcheddu, G. Giacomelli, M. Salaris, J. Org. Chem., 2005, 70, 2361-2363.


A. Porcheddu, G. Giacomelli, M. Salaris, J. Org. Chem., 2005, 70, 2361-2363.