Categories: N-H Bond Formation >
Reduction of azo compounds
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Recent Literature
An efficient Fe/CaCl2 system enables the reduction of nitroarenes and
reductive cleavage of azo compounds by catalytic transfer hydrogenation in the
presence of sensitive functional groups including halides, carbonyl, aldehyde,
acetyl, nitrile, and ester substituents with excellent yields. The simple
experimental procedure and easy purification make the protocol advantageous.
S. Chandrappa, T. Vinaya, T. Ramakrishnappa, K. S. Rangappa, Synlett, 2010,
3019-3022.
Various azobenzenes have been reduced to the corresponding hydrazines by using
an aqueous solution of sodium dithionite. The yield is generally excellent, but
two compounds, viz. 4,4-dimethoxyazobenzene and
2,2,4,4,6,6-hexamethylazobenzene, gave no hydrazine at all.
L. K. Sydnes, S. Elmi, P. Heggen, B. Holmelid, D. Malthe-Sørensen, Synlett, 2007,
1695-1696.
